Hyperthermia Research and academic articles
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Please note, there are many thousands of research papers on Hyperthermis. I post few only. Please take a look @ the
"International journal of Hyperthermia" for a long list of research, published over 40 years.
1) Noh, Jae Myoung, et al. “In vivo verification of regional hyperthermia in the liver.” Radiation oncology journal
32.4 (2014): 256-261.
2) Sugahara, Tsutomu, et al. “Kadota fund international forum 2004. Application of thermal stress for the
improvement of health, 15–18 June 2004, Awaji Yumebutai international conference center, Awaji island, Hyogo,
Japan. Final report.” International journal of hyperthermia: the official journal of European Society for Hyperthermic
Oncology, North American Hyperthermia Group 24.2 (2008): 123.
3) Bettaieb, Ahmed, Paulina K. Wrzal, and Diana A. Averill-Bates. “Hyperthermia: Cancer treatment and beyond.”
Cancer treatment—conventional and innovative approaches (2013).
4) van der Zee, Jill. “Heating the patient: a promising approach?.” Annals of oncology 13.8 (2002): 1173-1184.
5) Van der Zee, J. “Hyperthermia in addition to radiotherapy.” Clinical Oncology 19.3 (2007): S18.
6) Lepock, James R. “How do cells respond to their thermal environment?.” International journal of hyperthermia 21.8
7) Richter, Klaus, Martin Haslbeck, and Johannes Buchner. “The heat shock response: life on the verge of death.”
Molecular cell 40.2 (2010): 253-266.
8) Sonna, Larry A., et al. “Invited review: effects of heat and cold stress on mammalian gene expression.” Journal of
Applied Physiology 92.4 (2002): 1725-1742.
9) Moriyama-Gonda, N., et al. “Heat–Induced Cellular Damage and Tolerance in Combination with Adriamycin for
the PC–3 Prostate Cancer Cell Line: Relationships with Cytotoxicity, Reactive Oxygen Species and Heat Shock Protein
70 Expression.” European urology 38.2 (2000): 235-240.
10) Katschinski, Dörthe M., et al. “Role of tumor necrosis factor a in hyperthermia-induced apoptosis of human
leukemia cells.” Cancer research 59.14 (1999): 3404-3410.
A random, short list of studies.
Hodgkin AL, Katz B. The effect of temperature on the electrical activity of the giant axon of squid. J Physiol.
1949;108:37–77. [PMC free article] [PubMed]
Keszler G, Csapo Z, Spasokoutskaja T. et al. Hyperthermy increase the phosporylation of deoxycytidine in
the membrane phospholipid precursors and decrease its incorporation into DNA. Adv Exper Med Biol.
Dikomey E, Franzke J. Effect of heat on induction and repair of DNA strand breaks in X-irradiated CHO
cells. Int J Radiat Biol. 1992;61:221–234. [PubMed]
Yutaka Okumura, Makoto Ihara. et al. Heat Inactivation of DANN-Dependent Protein Kinase: Possible
Mechanism of Hyperthermic Radio-sensitization. In: Kosaka M, Sugahara T, Schmidt KL, et al, eds.
Thermotherapy for Neoplasia, Inflammation, and Pain. Tokyo: Springer Verlag. 2001:420–423.
Weiss TF. Cellular Biophysics, Vol. 1. Transport. Cambridge: MIT Press. 1996
Dewhirst MW, Ozimek EJ, Gross J. et al. Will hyperthermia conquer the elusive hypoxic cell? Radiology.
Vaupel PW, Kelleher DK. Metabolic status and reaction to heat of Normal and tumor tisuue. In:
Seegenschmiedt MH, Fesseden P, Vernon CC, eds. Thermoradiotherapy and Thermochemotherapy, Vol. 1.
Biology, physiology and physics. Berlin/Heidelberg: Springer Verlag. 1996:157–176.
Li GC, Mivechi NF, Weitzel G. Heat shock proteins, thermotolerance, and their relevance for clinical hyperthermia. Int
J Hyperthermia. 1995;11:459–88. [PubMed]
Stein U, Rau B, Wust P. et al. Hyperthermia for treatment of rectal cancer: evaluation for induction of multidrug
resistance (mdr1) expression. Int J Cancer. 1999;80:5–12. [PubMed]
Raymond U, Hiraoka M, Takahashi M. et al. Thermoradiotherapy of refractory malignant tumors: and experience with
microwave and RF capacitive hyperthermia. Medical Instrumentation. 1984;18:181–186. [PubMed]
Fuwa N, Morita K, Kimura C. et al. Combined treatment of radio-therapy and local hyperthermia using 8MHz RF-wave
for advanced carcinoma of the breast. In: Onoyama Y, ed. Hyperthermic Oncology 86 in Japan. Proceedings of the
3rd annual meeting of the Japanese Societey of Hyperthermic Oncology. 1986:337–338.
Goldobenko GV, Durnov LA, Knysh VI. et al. Experience of the use of thermoradiotherapy of malignant tumors. Med
Radiol (Russian) 1987;32:36–37. [PubMed]
Tsyb AF, Berdov BA. The use of local hyperthermia for therapy of cancer patients. Med Radiol (Russian)
Savchenco NE, Zhakov IG, Fradkin SZ. et al. The use of hyperthermia in oncology. Med Radiol (Russian)
Hamazoe R, Maeta M, Murakami A. et al. Heating efficiency of radiofrequency capacitive hyperthermia for treatment of
deep-seated tumors in the peritoneal cavity. J Surg Oncol. 1991;48:176–179. [PubMed]
Hiraoka M, Jo S, Dodo Y. et al. Clinical results of radiofrequency hayperthermia combined with radiation in the treatment of
radioresistant cancers. Cancer. 1984;54:2898–2904. [PubMed]
Kondo M, Oyamada H, Yoshikawa T. Therapeutic effects of chemoembolization using degradable starch microspheres and
regional hyperthermia on unresectable hepatocellular carcinoma. In: Matsuda T, ed. Cancer treatment by hyperthermia and
drugs. London/Washington DC: Taylor & Francis. 1993:317–327.
Sugimachi K, Kuwano H, Ide H. et al. Chemotherapy combined with or without hyperthermia for patients with oesophageal
carcinoma: a prospective randomized trial. Int J Hyperthermia. 1994;4:485–493. [PubMed]
Sugimachi K, Kitamura K, Baba K. Hyperthermia combined with chemotherapy and irradiation for patients with carcinoma of
the oesophagus: a prospective randomized trial. Int J Hyperthermia. 1992;8:289–295. [PubMed]
Sugimachi K, Kitamura K, Baba K. et al. Hyperthermia combined with chemotherapy and irradiation for patients with
carcinoma of the oesophagus-A prospective randomized trial. Int J Hyperthermia. 1992;8:289–295. [PubMed]
Muratkhozhaev NK, Svetitsky PV, Kochegarov AA. et al. Hyperthermia in therapy of cancer patients. Med Radiol (Russian)
Wang J, Li D, Chen N. Intracavitary microwave hyperthermia combined with external irradiation in the treatment of
esophageal cancer.[Chinese] Zhonhua Zhong Liu Za Zhi. 1996;18(1):51–54. [PubMed]
Shchepotin IB, Evans SR, Chorny V. et al. Intensive pre-operative radiotherapy with local hyperthermia for the treatment of
gastric carcinoma. Surg Oncol. 1994;1:37–44. [PubMed]
Kakehi M, Ueda K, Mukojima T. et al. Multi-institutional clinical studies on hyperthermia combined with radiotherapy of
chemotherapy in advanced cancer of deep-seated organs. Int J Hyperthermia. 1990;6:619–640. [PubMed]
Nagata Y, Hiraola M, Nishimura Y. et al. Radiofrequency hyperthermia for advanced gastric cancer. In: Gerner EW, ed.
Hyperthermic Oncology. Tucson: Arizona Board of Regents. 1992:407–412.
Hager ED, Krautgartner I, Popa C. et al. Deep Hyperthermia with short waves of patients with advanced stage lung cancer.
Hyperthermia in clinical practice. XXII Meeting of the International Clinical Hyperthermia Society. 1999
Hager ED, Dziambor H, Höhmann D. et al. Deep hyperthermia with radiofrequencies in patients with liver metastases from
colorectal cancer. Anticancer Research. 1999;19:3403–3408. [PubMed]
Hager ED, Dziambor H, App EM. et al. The treatment of patients woth high-grade malignant gliomas with RF-hyperthermia.
Proc ASCO. 2003;22(470):118.
Datta NR, Bose Ak, Kapoor HK. et al. Head and nech cancers: results of thermoradiotherapy versus radiotherapy. Int J
Hyperthermia. 1990;6:479–86. [PubMed]
Overgaard J, Gonzalez D. et al. Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic
malignant melanoma. Lancet. 1995;345:540–43. [PubMed]
Perez CA, Pajak T, Emami B. et al. Randomized phase III study comparing irradiation and hyperthermia with irradiation alin in
superficial measurable tumors: final report by the Radiation Therapy Oncology Group. Am J Clin Oncol. 1991;14:133–41.
Valdagni R, Amichetti M. Report of a long-term follow-up in a randomized trial comparing radiation therapy and radiation
plus hyperthermia to metastatic lymph nodes in stage IV head and neck cancer patients. Int J Radiat Oncol. 1993;28:163–69.
Vernon C, Hand JW, Field SB. et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast
cancer: results from five randomized collected trials. Int J Radiat Oncol Biol Phys. 1996;35:731–44. [PubMed]
Emami B, Myerson RJ, Cardenes H. et al. Combined hyperthermia and irradiation in the treatment of superficial tumors: results
of a prospective randomized trial of hyperthermia fractionation (1/wk vs 2/wk) Int Radiat Oncol Biol Phys. 1992;24:1451–52.
Emami B, Scott C, Perez CA. et al. Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy
alone in the treatment of recurrent or persistant human tumors. A prospectively controlled randomized study by the Radiation
Therapy Group. Int J Oncol Biol Phys. 1996;34:1097–104. [PubMed]
Sneed PK, Stauffer PR, Mc Dermott MW. et al. Survival benefit of hyperthermia in a prospective randomized trial of
brachy-therapy boost +/- haperthermia for glibostoma multiforme. Int J Radiat Oncol Biol Phys. 1998;40:287–95. [PubMed]
Kitamura K, Kuwano H, Watanabe M. et al. Prospective randomized study of hyperthermia combined with chemotherapy for
esophageal carcinoma. J Surg Oncol. 1995;60:55–58. [PubMed]
Berdov BA, Menteshashvili GZ. Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int J
Hyperthermia. 1990;6:881–90. [PubMed]
Hiraoka M, Mitsumori M, Nagata Y. Current status of clinical hyperthermic oncology in Japan.
Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med.
Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N
Engl J Med. 2000;342:1887–92. [PMC free article] [PubMed]
Ohno S, Tomoda M, Tomisaki S. et al. Improved surgical results after combining preoperative hyperthermia with
chemotherapy and radiotherapy for patients with carcinoma of the rectum. Dis Colon Rectum. 1997;40(4):401–406.
Colombo R, Pozzo LF, Lev A. et al. Neoadjuvant combined microwave induced local hyperthermia and tropical
chemotherapy versus chemotherapy alone for superficial bladder cancer. J of Urol. 1996;155:1227–1232. [PubMed]
Colombo R, Pozzo LF, Lev A. et al. Adjuvant microwave hyperthermia and Mitomycin C versus Mitomycin C alone for
superficial bladder cancer. Europ Urol. 1999;35(suppl 2)
Hager ED, Strama H, Hohmann D. et al. Prevention of cystectomy of recurrent bladder carcinoma by intravesical
hyperthermic perfusion chemotherapy (IVHP) Antic Res. 1998;18:4807–5006.
Van Rhoon G, van der Zee J, Broekmeyer-Reurik MP. et al. Radiofrequency capacitive heating of deep-seated tumors using
pre-cooling of the subcutaneous tissues: results on thermometry in Dutch patients. Int J Hyperthermia. 1992;8:843–854.
Datta NR, Bose AK, Kapoor HK. Thermoradiotherapy in the management of carcinoma cervix (IIIB): a controlled clinical study.
Indian Med Gazette. 1987;121:68–71.
Hornbach NB, Shupe RE, Shidnia H. et al. Advanced stage IIIB cancer of the cervix treatment by hyperthermia and radiation.
Gynecol Oncol. 1986;23:160–167. [PubMed]
Harima Y, Nagata K, Harima K. et al. A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB
cervical carcinoma. Int J Hyperthermia. 2001;17(2):97–105. [PubMed]
Harima Y, Nagata K, Harima K. et al. A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIb
cervical carcinoma. Int J Hyperthermia. 2001;17:97–105. [PubMed]
Nishimura Y, Hiraoka M, Akuta K. et al. Hyperthermia combined with radiation therapy for primary unresectable and recurrent
colorectal cancer. Int J Radiat Oncol Biol Phys. 1992;23:759–768. [PubMed]
Masunaga S, Hiraoka M, Akuta K. et al. The phase I/II trial of preoperative thermoradiotherapy in the treatment of urinary
bladder cancer. Int J Hyperthermia. 1994;10:31–40. [PubMed]
Rietbroek RC, Schiltuis MS, Bakker PM. et al. Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a
previously irradiated recurrent carcinoma of the uterine cervix. Cancer. 1997;79:935–942. [PubMed]
Harima Y, Nagata K, Harima K. et al. Bax and Bcl-2 protein expression following radiation therapy versus radiation plus
thermotherapy in stage IIIB cervical carcinoma. Cancer. 2000;88:132–138. [PubMed]
Masunaga S, Hiraooka M, Takahashi M. et al. Clinical results of thermradiotherapy for locally advanced and/or resurrent
breast cancer—comparison of results with radiotherapy alone. Int J Hyperthermia. 1990;6:487–497. [PubMed]
Nagata Y, Hiraoka M, Nishimura Y. et al. Clinical results of radiofrequency hyperthermia for malignant liver tumors. Int J
Radiat Oncol Biol. Phys;1197 38(2):359–365. [PubMed]
Hiraoka M, Masunaga S, Nishimura Y. et al. Regional hyperthermia combined with radiotherapy in the treatment of lung
cancer. Int J Radiat Oncol Biol Phys. 1992;22:1009–1014. [PubMed]
Hager ED, Süße B, Popa C. et al. Complex therapy of the not in sano respectable carcinoma of the pancreas—a pilot study. J
Cancer Res Clin Oncol. 1994;120(Suppl):R47P10415.
Hager ED, Dziambor H, Hoehmann D. Survival and quality of life patients with advanced pancreatic cancer. Proc ASCO.
Hiraoka M, Nishimura Y, Masunaga S. et al. Clinical results of thermoradiotherapy of soft tissue tumors. Int J Hyperthermia.
O'Clock GD. Effects of magnetic fields on health and disease. Dtsch Zschr Onkol. 2003;35:15–23.
Watson BW. Reappraisal: The treatment of tumors with direct electric current. Med Sci Rec. 1991;19:103–105.
Samuelsson L, Jonsson L, Stahl E. Percutaneous treatment of pulmonary tumors by electrolysis. Radiologie. 1983;23:284–287.
We have many more research studies, in case you feel it is imperative to
read further, please send us a message, we shall send few hundred more..